Clinical Changes in RPE

The pathological changes of RPE that can be presented in the clinical practice are in the form of:


-Pigment Epithelial Detachment (PED)

-RPE tear

-RPE atrophy

This course will discuss RPE's clinical-pathological changes; however, This course won't discuss RPE hypertrophy, RPE changes in uveitis, or dystrophy.


RPE is a very important layer which serves an important role in keeping a visual function, thus a disorder in the RPE layer may lead to the death of photoreceptors.